I'm purchasing the SnCl2 rather than making it (98% purity)
Yep, it's the same 2 Indians responsible for all the papers claiming Zinc/Ammonium formate can selectively reduce aldoximes. They're also responsible for claiming the same of Mg. There's papers not involving K. Abiraj and D. Gowda...
SnCL2/HCl is defintely the way to go to produce the oxime according to the paper I read (since my last post) yields are very high and all reagents are readily available . I'm aware about ethyl acetate being the key otherwise you'll get the ketoxime but it seems the reaction itself proceeds at...
Apparently you can do a Urushibara-like reduction in situ using a nickel salt dissolved in an ammonia solution and powdered zinc. There's also Al/Ni thats reported to work without the ammonia just a non-mineral acid. Yields are low though (30%) but thats not a major issue for me. I'll try the...
Isopropyl can be salted out to its own layer from the basified reaction mixture. Otherwise use DCM, petroleum ether or naptha.
If you can't get concentrated H2SO4 use phosphoric acid. You can use HCl but thats really a last resort.
NaBH4/Cu is what I've been using but I'm not comfortable purchasing NaBH4 constantly or in large amounts since lately its been getting some attention due to the FDA putting it on their special surveilance list.
What about Urushibara nickel as the catalyst in a microwave assisted hydrogenation as...
The acid isn't necessary. Coffee grinder aluminium foil is better. Doing both of these things will give you a more controllable reaction. Also wash your foil beforehand and put it in a 2% naoh solution until it just starts to bubble then wash again before amalgam preparation. This makes a better...
A Brief Review: Advancement in the Synthesis of Amine through the Leuckart Reactionby Qasim Umar and Mei Luo
https://www.mdpi.com/2624-781X/4/1/7
There you go, massive increases in yield and also speed.