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A tiny stain on the work-coat could kill many even by touch so it poses more organized workspace and conditions (given the danger and potency, this project should be approached with virgin glass wherever relevant) and thoroughly oxidized with piranha solution after. Most other contaminated...

Not a drop of the resulting acid will be sold!!!.... This is how I mean it. Late period I ran pretty poor and hours ago I got jobless. I have ***** future me in training and I help everyone for free on this forum even if I know it brigs big money to them due to my advice. I am willing to accept...

I wish everyone could answer like this! are you professor? (I call people expert pretty often but professor you got a rare compliment). I honestly never thought of the entire molecular assembly is to pass the BBB, knowing it is a prodrug I could have bet it’s hydrolyzed in order to do so...

This is the most easy preparative method. I shouldn't drop numbers since some while has passed since (bit over a decade) But it’s just the preparation of a NaOH aq. Solution to which gamma butyrolactone is then added in portions to just above neutral. With a magnetic stirrer it’s done in less...

In case you work the chemist way and use thin layer chromatography to check reaction progress. You will need a very tiny set of samples with the starting aldehyde (which you have) and the styrene as well as 2CHxHCl and the final product. I have a tiny amount of styrene to spare as well as some...

I also plan making it even if I may not be the first to publish it... I hope it will be good. I need a rotavap machine only since I have the glasssware for it, I also lack stirrers and stands with clamps maybe a large sep funnel. Looking forward to find the proper place. I was thinking of...

Anandamide, the endogenous transmiter is an amide of arachidonic acid.

I wonder what would be the effect if the chain is long and I have a kinky revelation right now which I wont spit here but myristoyl chloride is easy to make.

What is the 1N acyl on this one (1P, 1A, 1*****) I know. Normally the N acylation should be done on the precursor (there is a chance of acylation as a last step) so you can make all the types from the same LSD, depending on what acyl chloride is at hand. Propionyl is popular and easy to buy.

In this very particular situation the liquid is weighed for precision... volumetrically you need a micropipette to get accurate quantities. Some times precision is decisive in synthesis, also methyl-diethylamine NMe(Et)2 needs to be precise. Large volumes are seldom weighed.... since volume is...

If done the chemist way, it should end up with nor-LSD but not mesylate salt. Ssince the product is closer to neutral (amide) but more basic than LSD due to the fact that it has a proton instead of methyl on the quinoline moiety nitrogen atom.

You may try NaBH4/CuCl2 method if LAH is too scary for you, or you are newer to preparative chemistry. LAH can spontaneously ignite if miss-handled or kept in ambient for long enough.

It so happens that diethylamine is not regulated in some countries and I have access to it, so subgram quantities can be thought of sendable especially in a protected form. Within this particular synthesis I think it can be eluted through GF254.

The difference between organic and inorganic chemistry is unrelated to the shampoo label... I’ve seen “organic table salt” which is a supreme lie in it’s own meaning.

I also remember having a quantity of bupropion but in the end I got discouraged since there was no viable method to clive the tert-butyl moiety from the amine. Anyway the plan is a waste of time, it is much more advised to synthesize captagon from amphetamine.

Acylate toluene with propionyl chloride in presence of AlCl3 to perform a Friedel-Crafts reaction.

The synthesis of the 4-methyl propiophenone is a very classical Friedel-Crafts acylation of toluene with propionyl chloride in presence of a strong Lewis acid such as anhydrous AlCl3 that only has a tiny amount of 2-methyl-propiophenone. Now brominating the product with bromine in acetic acid or...

All seems easy with just the theoretical knowledge, the methylation of that specific carbon is not just going to happen before the quaternarization of the nitrogen to trimethyl betaphenylethyl ammonium ion, so amino function must be either protected or transformed to lengthen the chain. Which...

The chat also evaluated the lack chemistry skills from the first question, therefore the answer suggesting the asker to understand more chemistry. If you knew any practical organic chemistry or the difference between the ortho and the meta positions you would have maybe figured out that there is...