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Careful, metal reactors usually have a coating inside to keep them inert from the mixture. Glass is not only transparent and inert but also heatable to some extent. Polyethylene (HDPE and LDPE) as well as polypropylene are inert but not transparent nor heatable. Scale-up should come with experience.

All cannabinoids natural or synthetic are organic! The only psychoactive inorganics I ever heard of are N2O and Xenon

Moisten the paper and let water (or solvent) fully dampen the filterpapers before applying vacuum that needs not to be too sudden

You need to convince your carbonyl group to make an ester with methanol and ethanol respectively. This is pretty straight forward by standard chemical means and try looking for rather mild methods such as enzymes (lipases) or easy to work with ClSiMe3 in methanol with substrate.

I am somewhat unsure but out of reading Tihkal on countless occasions, it was fixed in my mind that indole will react on C3 to form an indole-glyoxyl chloride which is one carbonyl longer than what is shown in the diagram.

You need to understand the stoechiometry of the reactants and their behavior towards solvents and physical factors such as heating, cooling, solubility, etc... all this in the frame of time.

as any ester it can undergo acid or alkaline hydrolysis, the latter is more used.

Please speak the language of chemistry as well because the understanding of phenomena happening during synthesis I wish to endorse the most. Do not deliberately use the word cooking instead of synthesis, perhaps the word preparation should do. I assume most fear learning organic chemistry and...

Yes, tosylic acid is PTSA and triflic acid is trifluoromethanesulfonic acid, I will let you search what AIBN stands for... just like a little practice (you will also read a short description that is like a brick in the wall of chemical knowledge you possess). STAB is also a good to know material...

I am glad you aren’t thinking about financial benefit when you do Chemistry. The feeling you get when taking something you made yourself or got from someone whom you thought the preparative dark arts. In this moment I am enjoying some D-amp from a mate who got to be a chemical engineer from my...

It also may be likely that melatonin hydrolysis would be simpler and more high yielding than decarboxylation of tryptophan. There is also a gap in price... regarding tryptophan you should know that LD (racêmic) is as good as the optically pure L-Trp just in case it’s cheaper. I’ve seen melatonin...

Good question, the alkylation of nitrogen occurs via the temporary formation of an imine (double bonded carbon with nitrogen) which is reduced by STAB which is the most selective for imine reductions. If you want the both substituem-nos of the nitrogen to be identical it is much simpler by...

From melatonin you can get 5MeODMT, 5MeODET, and só on. For simple ones like DMT, DET and só on you start from tryptamine.

Regardless of the yield, you’ve done a good job. I would still go for basic hydrolysis but this is a nice description of the preparative approach for acid hydrolysis. As you mentioned yields can increase by means of distilling off MeOH that is well known to aid in removing acetic acid, you can...

Symmetrical products are easier to prepare, such as DMT, DET, DPT and DIPT that has curious effects on the diisopropyl tryptamine (without 5MeO) the effects are 100%auditory. 5-MeO-MIPT is cool but trickier to make also from mexamine.

Well melatonin is available in bulk quantities for a relatively low price and melamine is easy to obtain from it in decent yields, 5-MeO-trypamine is also sold by some here on this forum (check the listings). From comercial mexamine (5-MeO-tryptamine) is better since it may be expectable to have...

It’s fenomenal news given the circumstance can you give the enantiomeric ratio and yield, perhaps concentration of agents and substrate with the volume of solvent. Or at least a beilstein style short description of procedure that I can develop on with the least amount of R&D time and losses...

First of all is somewhat clear that D-LAME is the starting material and we aim to preserve chirality at all costs, peptide chemistry is pretty much like this but has also need for a great yield since it’s repetitive, and cumulated losses make the product expensive. We can assume a slightly more...

Very good question, alkaline hydrolysis is bound to racemize the product which you most probably don’t want. I imagine that the new method with carboxyl activator can be worked in such way that hydrolysis occurs in tandem with the amidation thus leaving the substrate chirality the way it is. The...

Designing psychedelics is much much safer... I’m afraid I can’t promise safety with no bioactive steroid, the effects must be determined by testing them and hepatotoxicity is not to be guessed. I wouldn’t try them on myself.