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medazepam as a recreational benzodizaepine it isn't what users want but maybe as substitute.

several hrams would do to you.... why not a dosen, but some of us are confident to peerform such asynthese

diisopropyl ehyl amine maybe...

The answer is obvious enough not to answer and encourage you to find out for yourself (it will help you)... do you have multigram quantities spare... I would absolutely love some.

Phase transfer catalysts generally have in common their amphoteric properties (soluble in both phases) and this soapy property also ensures they are super difficult to remove by liquid-liquid extraction, at least. NMP can be regarded in the case of a DCM based synthesis as something similar even...

If only you respect the stoechiometry...

You bet there are some fundamental stuff you absolutely must know before you start implementing in practice as well as there are most that you will learn on the go but the first one should be figuring out a number of the stuff you need to document by yourself then ask again. you need to think as...

You present yourself as a future chemist on a good track and you are invited to value my statement as I tend to discourage anyone asking to take for granted and be stubborn on his personal hocus-pocus view. Accept the fact that you need to climb your way and the first steps are the slowest and...

It's not the freshest topic in my mind and I do remember to largely agree please master this on a small and manageable batch size as I promise if you prove i can get you thank me and benefit quite a lot. As I think of chemistry being somewhat sacred, I need you to deserve the profitable scale...

As much as it's in your best interest, hit me up and don't expect to check my messages daily. Every few days I tend to be around, no more than a week...

If you happen to be EU based (also if you're not to a lesser extent), I may be able to promise you good news. As my sacred mission is to separate drugs from money eventually, I'm not that much into becoming rich but quite on the opposite. I can give you hope for as long as you are fair, what you...

I also did some tryptamine Pictet-Spengler and Bischler-Napieralsky cyclizations during my M.Sc. research but some esterification forced my attention towards a slightly different but equally interesting topic of multicomponent reactions. Such as Mannich condensation reactions. I since then found...

About specific questions: I have no clue RPM wise, but for sure overhead stirring is advised vs. magnetic in this case (at least at the precipitation step the volume is large and if solids form, the stirbar may get stuck).

Catalysts I worked with either heard often about are n-buthylamine, cyclohexylamine, ethylene diamine and even monoethanolamine. Ethylamine also works despite it being a 70% solution in water.

Dihydrolysergic would be much more difficult to oxidise back with specificity and for brominated analogs I thought of 2-Bromo which in turn could be dehalogenated with more precision via Grignard followed by hydrolysis, I remember someone claiming to do this with the inactive 2-Br-LSD.

Structure-activity relationship suggest bad interaction between the alpha methyl and the N-benzyl moieties.

is that dihydronorlysergic acid?

As far as I know dihydroLSD is somewhat less potent

metonitazene is there right after fentanyl, the rest are also there and I urge @FENTAMAS not to reveal more than he did, since opiate fans + knowledge of chemistry have been previously proven to be resulting in disastrous MPTP induced tremors like PD.

Reduction works fine also with Al amalgam and Cu2+/NaBH4 and I got stuck at the halogenation for which I am truly feeling humiliated by chemistry because I have done much more difficult ones in the past.