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LSD, DMT, Psilocin, P***** and Ketamine all bind the MT2 receptor extremely strongly. Much more strongly than the 5-HT receptors usually considered as the source of psychedelic effects. Ligand MT2 (kj/mol) 5-HT1A (kj/mol) 5-HT2A (kj/mol) 5-HT2C (kj/mol) NMDA (kj/mol) LSD -41.9 -34.44...

This is just an idea at this stage. Any feedback is welcome. 1. Photolysis of acetaminophen https://link.springer.com/article/10.1039/c2pp25341k 2. Methylation of 2-amino and 3-hydroxy groups using methyl iodide 3. Alpha keto chlorination. I'm guessing this will chlorinate the 4 position as...

5-HO-aMT from acetaminophen 1. Photolysis of acetaminophen https://link.springer.com/article/10.1039/c2pp25341k 2. Alpha keto chlorination https://sci-hub.se/10.1080/00397910500334637 3. Indoline formation 4. Aldol condensation with acetone 5. Reductive amination (1) can also be used to make...

Thank you very much!

You have been. I really appreciate the feedback. I don't have a formal background in chemistry or pharmacology, so I was hoping to my work checked by this forum :)

Epitestosterone is a positive allosteric modulator of the GABAA receptor. It appears to be neuroprotective and a high testosterone / epitestosterone ratio seems to be correlated with autism. https://pubmed.ncbi.nlm.nih.gov/33535392/ SARMs are definitely something I am looking into. They seem to...

Do you have any reason to believe 17α-testosterone (epitestosterone) is toxic? It is an endogenous steroid that exists at concentrations of approximately equal to testosterone.

It turns out 17β is the kinetic product and can be produced with good selectivity (17α: 3%, 17β: 97%) using NaBH4 alone. https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.202100967 The above study also shows MPV reduction has moderate selectivity (17α: 34%, 17β: 66%). I...

It looks like this can be simplified into a 3 step process. 1. 3-O Oppenauer oxidation with simultaneous alkene rearrangement to conjugated position 2. 17β Enantioselective reduction by Saccharomyces cerevisiae (bakers/brewers yeast) 3. 17β Esterification I haven't found yields for...

My intention was to start the discussion of testosterone synthesis as I couldn't find much online. If this is the wrong place to make my post I apologize.

Below is the synthesis of testosterone from DHEA provided by Patrick Arnold. Protection group has been inferred and reduction method is unknown. 1. 3β-O Protection with TMSCl 2. 17β Enantioselective reduction 3. 17β Esterification 4. 3β-O Deprotection with TBAF 5. 3-O Oppenauer oxidation with...