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Is everyone in this thread mad? You are not going to ***** around with aluminium amalgams, HCl gas, Grignards, phenylhydrazine and so on and then say that NaBH4 is out of the question. If you want tryptamines, you do reductive amination on tryptamine with NaBH4 or whatever else, or the Shulgin...

But don't you need to first reduce the imine formed by the reaction of the tryptamine with acetone? That is Base tryptamine + acetone -> imine imine + nabh4 -> isopropyltryptamine isopropyltryptamine + formaldehyde -> another imine this another imine + nabh4 -> MiPT I didnt know that the...

The Henry reaction is legendary, but just one thing: I don't get the ammonium acetate. It seems to be present in every single such reaction, including all of Shulgin's work, yet I've never understood what role it serves? Is it a catalyst of some kind? What about the sodium acetate?

I don't grasp the order of the reactions, why do you add the formaldehyde before the NaBH4, wouldn't you first want to reduce the isopropyl-imine to the isopropyl-amine, and then add the formaldehyde, and then reduce it again, yielding MiPT