i want to ask if any of you have experience with best method and rates and tempratures for the reduction , i specifically talking about 2,5 dimethoxy-NS to 2ch
lets say something like this my friend tried.
A 2 neck round bottom flask containing a 1:1 mixture of IPA:water by weight (250g/10g...
i cant get 48% hbr from a seller , so i want to ask if its possible , will it work ? because i did brominate 2ch like that , so i wonder , and if so and what ratio and what scale will it work.
dude i dont know why the insisnt on nmp in this forum , dcm with give you much higher yields and easier workup , dcm can yield 70-80% where nmp can be anywhere with 20-50 %
if you get blue product it means there is too much methylamine in your organic layer , wash it with salt water 5 times and acidification should go better
the blue color is methylamine residue i think , i did the reaction and all went well until acidification also , then powder participated and after x<ph 7 it turned blue , but i was able to wash the powder with acetone and it became white
maybe you didnt add enough water to dissolve the...
did you find out why it was blue? , i followed the sythesis with 25g of bk4 and after adding 1:1 hcl acetone to the RM at one point it kinda solidefiend for a sec , then redissolved , then turned blue and bluish poweder praticipated ,
750g is a good yield i hope i can get this much.
when you refer to dcm\toluene , you mean the sythesis from 4mp right? because if you use bk4 then its only and extractor and temp doesnt matter
So lets try to figure stuff out so we wont waste precursors.
we have 2 ways
1. from 4MP we brominate -> methylation
or we skip bromination and get 2br4mp and just do one reaction.
i saw various posters run into trouble so we will try to solve the problems one by one.
Synthesis...
yeah so i posted a way with the hand written chart , looks viable ? they make it somehow in the netherlands and the drug is not expensive so i guess they have a good way