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Hi guys, I'm really struggling to form the tartrate from the freebase. This was my third trial, the first two were kinda messy and solvent probably not anhydrous, the amount of tartaric was also eyeballed to prevent losses from transferring the freebase flakes in a container to be weighted. I...

Bro it's not how it works, my eyes are bleeding. CaCl2 absorb water freeing the HCl as gasseus

Bro Throw in the bin 5 century of chemistry in two sentences

I don't think it's worth on the LA, probably with a good workup and enough experimentation it's not even need on the final product. Big acid chemist like pichard used to synth kilos every month, and I really doubt they were able to chromatograph that amount of product, nearly impossible with a...

Get reasonably pure LA is a pain in the ass, nearly all the hydrolysis lead to brown/black product which as to be purified. Even with good quality LA the coupling reaction mixture gets brown black and the work up is not as simple as it is stated (maybe if you start with 100% pure precursors...

Few mg of dithionite are used in some patents as antioxidant.

I report anhydrous condition aren't needed

You didn't mention any hydrolysis in your post, which is very unclear. Also if you start with PMK et-gly you need a basic hydrolysis first to get the carboxylic acid from the ester and then the HCl process to convert the epoxide to ketone liberating CO2. If your start material is real and you do...

Are you even serious? Seriously man I'm really surprised you even had success in any synth. PMK methyl/ethyl glycidate IS NOT PMK. Otherwise there wouldn't be the two words methyl/ethyl glycidate after it, don't you think? It CANNOT be used for synthesis for the simple reason it is not a KETONE...

LoL man, isn't it because they test freebase quantities of the product and not the salt? MDMA HCl is 84% freebase by mass

Solved, didn't see the double bond

(13) is lysergic acid methyl ester isn't it? Also would a simple hydrolysis with KOH (like LA synthesis from ergotamine) work? I mean what is the nickel and the arsenate role in the reaction?

Will the hydrated form of LA work the same or it has to be dried?

Thanks for the confirmation, may try in the future when I will have some money to invest in the process😉

Could lysergic acid methyl ester be used instead of ergotamine? Would the basic condition hydrolize the methyl ester? If this works the rest of the procedure would be the same. Using methyl lysergate would make LSD synthesis really user friendly and cheap. Any advice is appreciated😉

Thank you for the info dear, I will definitely look into it

Would it be possible to convert psilocin to 4-Aco-DMT with something like acetic anhydride? Or the molecule couldn't survive the process? If it is possible do you know any possible route? Thank to everyone in advance, any help is appreciated 😉

Hi, if you start with the sodium salt, should the basification process with NaOH be skipped or is it needed?

Thank you very much for the explanation ;⁠)

Hi, hope this is not a stupid question. Is IPA suitable for Indole-3-yldiethylglyoxylamide recrystallization? Checked the boiling point and it also seems suitable for removing excess diethylamine. Thanks in advance for your help.